Currently I'm at just under 100k genomes with at least one of each genome upgrade I've seen. It is fun in the beginning until you realize every upgrade other than speed is next to useless. The game also caused my hands to start to hurt through the monotony of merging all the speeds needed to die.
The other upgrades do have minimal use at the far end game where you use a singular efficiency to stay alive and you use one or two runs of stocks to make money, then just blast through with speeds to make a bunch of genomes. The game also seems to have quite a few errors like the bonus genome choices never showing up, a whole upgrade in research mentioning that it unlocks merging, when it actually unlocks amplifying, and efficiency being way too powerful (at least I believe this is an error because it just skyrockets in power from level 3 to level 4 to such an insane degree).
On the uniqueness front, while the genome system is unique in that it rewards you with being unable to buy upgrades and the choice of stocks being time-based instead of random (love this by the way, any game with stocks should do it this way), the game as a whole plays fairly similar to other time loop games.
As a whole, it was a fun enough time, but physically painful gameplay and horrid balancing really dragged the game down.