This is how I run games made with TyranoBuilder on Linux. It should also work on Mac but I'm not sure about how to open a browser with allow-file-access-from-files on Mac (found some tutorials but they might be out of date), so you'll have to search around.
Open the file resources/app/data/system/Config.tjs in a text editor and edit the line ;configSave=file to ;configSave=webstorage
Open a browser with the "allow-file-access-from-files" flag set. (This allows the game to properly load the local files it needs to run.) In Ubuntu, you can run google-chrome --allow-file-access-from-files in a terminal.
Open (drag & drop) resources/app/index.html in the web browser.
Hope this is helpful!