no. But i figured out is for a really good reason as it seems there is an easter egg right when you first start the game and the door is closed so you cant get the easter egg later in the run it has to be in a new game.
No, but there is a secret 'dev' area behind the closed door at the very beginning of the game (right after the opening cutscene, after you wake up). You have to try opening this closed door 100 times or so. If you don't believe me, start a new game and see for yourself :P