Really cool game, kinda made me addicted :) I really like the concept, and could literally not stop playing, until the game somehow crashed on the last enemy xd
While I don't know why two runes for static effects (Bleed, poison etc.) exist, I found it really helpful to see the toolboxes with the info's to each rune, but I found out about that after the first enemy, so it would be cool if you had like a little tutorial at the start, especially with your kinda complex system. A little particle/visual feedback would be also cool for shields, attacks and so on.
The enemies look insane and I really liked the graphics/idle animations. You should continue working on this game for sure! One of the more fun games I've played yet!