I won! It is addictive :p
I settled on having lots of life gain and precise weakness cycles. Then, I tried to always have 3 colors in potions.
But I feel that with the wrong start, the game can’t be beaten (only minuses, or one color doesn’t have minuses). I rerolled quite some times.
(and I cheated a bit: when you pick a + or -, if you quit the level faster than the animation, the modification is not taken into account, it helped to avoid unwanted minuses).
Awesome work! On Pico-8, I am impressed.