It seems like sometimes items can lose effects they receive from relics, very likely on reorganizing during combat. Just lost Shield Spirit effect on my shield and Frog Totem on the wand at the same time, was wondering why my weapons stopped trigger after reorganizing. It isn't critical for my particular setup as I was able to reorganize again and received stats back, but might kill many people otherwise by demanding 3 extra energy to fix it.
Also I've only noticed it now but it happened few times with wand and fluff relic before, I just had no idea why sometimes wand recovers 2 mana on use and sometimes it doesn't.