If you are new to the game I would suggest you to disregard the other suggestion since it requires heavy foresight, luck and preparedness which is difficult to follow through for newer players.
Although I have played the game for over a month, I only ever got a cleaver build running once, an archer build running 8 times (6 out of those 8 times were thanks to Matthew), so my recommendation would be to stack up on armor pieces because enemy spikes and burn become irrelevant anyway with a hefty block.
The archangel armor and the plate armor are both very good, the former gives haste, the latter adds 8 block which is massive! Then, there is a bug that causes the ninja suit to add armor instead of removing it if you are affected by haste which again the archangel armor provides.
Your last concern should be poison because right now you are practically invulnerable.
To counter poison you can use a combo of both a cleansing rag, plus either a vampiric gem or a heartstone gem. Alternatively, if you run a mana-based build a my first wand will always recover all the health you have lost due to poison.
As for damage, I recommend a full-on magic build, it is an easy build to get going for newbies because wands deal extra damage on top of your action turns which you can use to refill on mana thanks to the spellbooks.
Although yes, an archer or cleaver build is objectively superior and will always get you farther in endless, it is difficult to build. Then again, as a long-time player, I struggle to get those builds going because they require lucky drops and foresight. Even when I did get the build running, it would not scale well in endless because I stop findind the items I need. For cleavers, I had like 9 of them queen, king, golden and normal in my inventory, and yet, I could not progress farther because that was as powerful as my character was gonna get by the end of the day.