I had a fun yet predictable build. I used the Assassin's Dagger and just scaled it as much as possible. Ended up doing 405 damage on hit, although it does take two energy every time.
Here is my death inventory:
I got two Golden Whetstones that I used for 25% permanent damage each as well.
Before I got the relic to give me one extra energy, I had a Dagger on the left. I got rid of it once I could use Assassin's Dagger full time.
Here is the final damage I could muster out of the Dagger with all of the mana stones adding +2 each used time. I had also killed 100+ enemies with it, so it scaled nicely because I got it early in the game. I also find it hilarious that my armor was very early game at this point, but I got unlucky with all that. I am also a beginner so I most likely missed a lot of good synergies and important armor pieces.