I just finished playing for the first time and it went great! The gameplay is tense and addictive and the world and story laid out in the book are dark but engaging.
I largely focused on the mechanics and briefly imagined the narrative repercussions of my rolls in my head, but I think the game would be even more rewarding to those who want to flesh out their character's story by treating the results of rolls and character sheet decisions as journaling prompts. The game is written succinctly enough that focusing on the gameplay is fun, but evocatively enough that elaborate stories could be created by those so inclined.
The gameplay does a great job complimenting the genre it's residing in; it's a horrific world where corporations control everything (perish the thought!), and so the dice are stacked against the player from the get-go. As such, it's definitely useful to start playing with the knowledge that you'll be losing a lot, both in terms of your character's resources and in competition against your corporate enemies. With that in mind, it's a great time and I highly recommend it.