You would need the relic that activates weapons adjacent to weapons. I posted a screenshot for that in this comments, but it would make defense and offense at the same and make the cleaver cost just 1. The negative effect can be easily avoided with cleaver.
But unless you are able to kill both of the front guys, you will probably die. You would need something like the stone that adds weakness to your weapon to deal with your setup and reduce their damage by a lot.