my first good run, started of with a pickaxe build so that explaines all the gems, died att floor 23 to poison
if you want a 100lvl run I suggest butcher knives
highly recommended butcher knives with the following items
Belt of Knives, stopwatch, windmill, duct tape,shield, shield spirit, cleansing flame and a lot of chefs hat(these are the necessary items to do a butcher knife build)
most important items is cleansing flame, duct tape and belt of knives and shield spirit
belt of knives so the more you attack the more you deal damage(note that you have to read it carefully to actually use it at its fullest, it was my first mistake when i made my first butcher knives run)
cleansing flame so that the spiked enemies deal less damage like king, rexecutioner, and the spear lizard thingy
you could also consider putting 2 vampiric items but I highly recommend the diagonal ones since they don't interrupt any butcher knives
if you dont know what duct tape does i suggest searching backpack hero butcher knives on youtube