I think I'm jumping in?! Ore a horror game of outer space mining. Not an uncrowded field but this take would emphasize the temptation to mine in dangerous places (thus taking on risk and wearing down your dice to gain Credits) against the characters' individual (crushing) debt ... with a random interest hike rolls to ratchet up said debt if they aren't pulling in a high enough yield! Want to mess a bit with the core expectation of being able to 'catch your breath' by making oxygen supply a crucial and often endangered resource (and removing oxygen entirely if your session runs over its stated limit)!
Mine for iron, mine for diamonds, skim H3 from gas giants, drill ambergris out of space whales...all for the sake of someone else's profit!