Nifty idea and setting. Drug-fueled paranormal spy-fi has potential and your setting puts a fascinating lens on the Swinging Sixties. I also like the way you pared down the list of FIST traits to better fit the genre.
There were a few issues you might want to tweak. The dosage die on page 6 rules need some cleanup. It looks like there is some missing text and even without it I'm not sure how it works. When does burnout happen? Also it's not clear if a drug is physically taken to activate a weird trait or if it is a mental switch. Mechanically there is no difference, but it would affect player actions. Can they go weird if tied up?
On page 9, there's a spelling error, "The bowls of PBS itself" should be bowels. Also I'm not sure if the use of PBS, which is also the name of the Public Broadcasting System, is intentional. If not you may want to change it to "the Project" as it is jarring.
I like the Clutch trait, especially as it encourages the donning of sunglasses ala CSI:Miami. I might also put the OTS sections closer together for easier reading, but otherwise a great entry.