The most likely cause of crashing during play would be having mods installed or manually altering the program files. If the progress was started or played with a mod installed, then it's possible that your progress was altered or corrupted. Also note that mods do not re-apply themselves if you reinstalled Strive or replaced files in the Strive program folder.
You will need to provide your game version and a complete list of mods and their versions for me to determine likely problems. Also sharing the save file will allow me to see what is wrong with it. You can share the save file using Discord (https://itch.io/t/284398/discord) or use a file sharing service and provide a link here.
If you have a 64-bit installation of Windows, then you can attempt to investigate the cause of the problem yourself with the Debug mod (https://itch.io/t/1137280/debugmod-v1) and post the error messages here. This mod has the side effect of stopping most crashes, but this will not fix your problem.