I made a great progress with loudout that damage 100-500 damage per turn, Then this green mf showed up. I died because of his spike.Now I learned that I need ranged weapons.
I died at floor 8 :c
In that build a shield instead of those two jugs would have been enough. It's a bit tedious but you can just block for 7 turns to reduce those spikes to 0 and then attack.