Good art direction! Would have been nice to hear things, but I know that sound can be frustrating, so I'm not holding that against you in a 48 hour jam.
This game itself, though, is frustrating. This could just be me, being easily really frustrated by roguelikes, but there is a terrifyingly high standard deviation for luck here. In one run I got 7 hearts and put at least 30 tiles down before finding something that could harm me. In another, I was literally surrounded at spawn by enemy spawners and pools of acid.
It's also hard to read at times: it didn't even occur to me that the game actually told me which tile I was about to place, it takes me a moment to tell if I was actually hit by an enemy, and the health bar colors are switched (red means health, green means damage).