I use Defold mainly to forget about multiplatform issues - including html5 port.
The result is lightweight (and that's something I care a lot about) - Lua isn't hard to use, even when you're in a hurry - and compared to what I did before (multiplatform c engine, html5 done using emscripten) using Defold is surely less tricky - and faster.
If you're already a programmer I suggest you give it a try - but if your goal is "just" to make a point'n'click game and you're not already a coder check AGS or Visionnaire before that.