Well, I'm less concerned with Strength for the sake of grappling offensively (heh) and more for the sake of snapping out of enemy grapple attempts basically instantly. I learned from the harpy on my first attempt that getting grappled by some enemies can leave you with those game-over inducing Perks, and I've read that the naga can flat-out kill you via grappling. Having an answer to that seemed worthwhile.
Also, this is pretty freakin' niche, but as far as I know, you can't get into the Manor in Monster Town without either Strength or Magic, and that seems like a reasonably important quest? Not sure I'm gonna say being able to do one specific quest is worth picking Strength over Agility when Agility has so many other things going for it, but I felt like it was worth acknowledging.