I guess it depends on your HP and how you set your deck up, I am at 36800 HP so I can usually take the initial hit. My first hit usually > opponent HP.
you mean initial (opponent) hit? Yes, sure, but I'm talking about 3d turn (opponent) fully charged hit. After those toys\potions\libido dust\ultimate ability implementations it can easily be 500k damage.
upd: I mean yes, technically you can make one-shot on 2d turn if your opponent not invested in HP , but its even more random. Example: my set do initial hit from 11k-34k, that's a huge difference!