There are a bunch of ways to do animated tiles in 3d, but there isn't any thing supported out of the box with Sprytile. But because Sprytile is inside Blender, there is a lot of flexibility in how you can achieve animated tiles.The approach you take will mostly be dictated by where you'll use it.
I don't really have the time to elaborate on how to achieve sprite/tile animations for now though, sorry about that. Maybe some other people in the community might be able to help here.