It's extremely hard to get red berries for the Strong Restraint Pots if you are at -100 with the wolves. I've kill more than 50 wolves and had to resort to save scumming. While I understand that they are hunting me, when you kill 6 packs of wolves they should get the memo.
Edit: Went back to another save 18 wolves killed and only got 7 red berries.
Edit 2: Maybe a maximum amount of encounters per day? I have a 8 perception if it matters.