There is no need to do anything. You simply download the new version, and play the new version. You can delete the old version if you like, as saves are stored somewhere else.
Hi Runey. I just learned about your project and it looks great. I don't see any details about VR support for WMD headsets like the Samsung Odyssey. Are you planning on implimenting VR support down the line? Honey Select, PlayHome and Koikatsu all have great VR modes. I'd like to check out Harem Hotel in VR. Hope to hear from you.
Someone did a demo of how to make Renpy produce 3D SBS images with depth - see https://lemmasoft.renai.us/forums/viewtopic.php?t=25178.
Actually implementing a VR version of Harem Hotel may prove to be far too much work to be practical, but it's not actually impossible (at least not down to the limitations of .Renpy)