I played the web version, and the shattered ceramic if you get enough(3+) they kill the enemies so fast they are ghosts (Invincible but can still attack), And if you get a shit ton(6+) of the shattered, your game just breaks, so warning I think 5 is the limit
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Actually, its the really high amount of projectiles that causes the lag, for example, if i have a really high rate of fire, from 3 times gattlingun item + high rate of fire in general + homing + ricochet, picking the shattered shot item even once can crash the game when fighting the wollum toad and its 4 minions.
Those ghosts enemies are invisible, not invincible, by shooting at the position from which the ghost fires, you can kill them, fortunately only ranged enemies can become ghosts.
Also in the wetlands levels, where enemies are the most likely to become ghosts, the floor is covered in water, which gets disturbed when the player and most enemies move, making it easier to figure out where to aim at, and the only flying enemy shoots constantly behind itself when moving, which gives away its position.