Hi! First on the pep pills, yeah it's intentional. I read on drug use during WW2 and something akin to pep pills were very common. (I believe 'Pep pills' were even a name used for them in some parts of the world) I don't remember why I specifically mimic'd that packaging though.
I don't really understand what you mean by 'misaligned' tilesets? They are formated for RPG Maker MV. There are no autotiles used in the game. (at least what is referred to autotiles in RPG Maker) Every tile is manually placed on the map. I know the tilesets have very confusing layout. I never made them to make sense to anyone but me, so yeah...