I work with a 64x48 (64x32 surface, 16 depth) for tiles. I noticed that these seem to be perfect, when I get rid of the whitespace on either side it's 128, so that's a simple 0.5 reduction. Definitely going to automate and touch up...might not even have to touch up as much!
The older set I did this on was like a 0.39 reduction haha, now that needed some touching up.
Viewing post in Early Access: Village Interior Tileset comments
I'll definitely show you my results. Some early testing with the floor tiles show a lot of promise. The objects are great and I'm already using some of them as "portraits" for things like Chest, Shrub, Vase.
I decided to go with the smaller size due to time/effort needed to create new tiles. Most of the tiles I was using I had resized x2 anyway, so they sort of already were 64x48.
For me, at higher resolutions, it looked better if I scaled them by hand and included multiple tilesets (larger file size of course). There's a lot of difficulty with pixel art and resolutions, haha.