Once I found a comfortable hand position, it played great! Pressing the B button with my d-pad thumb is what really makes it work.
No less comfortable than how I hold it the other way. And there’s enough of a border that nothing gets covered by my thumb. I will admit, though, I’m 6’ tall so people with smaller hand may have a different experience. After playing for 2 days, this game would feel way too cramped on the screen in normal orientation.