To describe a typical play session that I am aiming for. Player travels a galaxy. One star system at a time. Exploring. Searching. The goal is to survive the exploration and encounters along the way and to find a faction leader and exterminate them and gain their system access card for the current system. This unlocks the next star system to warp to. Each time a faction leader is killed by Cynthia, Jakes gets closer to his goal of ending the war. So does Cynthia... because as promised, Jakes removes an augmentation and she gets closer to being human again, but she is weakened every time... The game end goal is to survive, explore and exterminate all faction leaders against all odds (ever increasing weakness, RNG etc). There are 5 augmentations so therefore there are 5 faction leaders to neutralise. One in each star system. You need to explore to find them.
That is my best explanation for what I am attempting to achieve here :)