The InRelief engine has Python and Lua implementations; I used it with Pygame and Love2D, respectively, but the resulting games flopped on both platforms, and I gave up.
The EightWay engine mainly has a Javascript implementation. You can see it at work in Electric Rogue and Glittering Light 2. I also ported it to Python for an experiment (involving Tkinter), but meh.
Keep in mind, these are strictly graphics engines. The games are hand-rolled otherwise. Thanks for the nice words!