Because RPGMaker MV is based on NW.js (formerly Node-Webkit) you can download the Linux version of NW.js from https://nwjs.io and copy those files over top of the NW.js files that the game shipped with then run the nw binary.
That’s enough for ~80% of RPGMaker MV games, the rest have case-sensitivity issues so I’ve just been running all RPGMaker MV games on top of ciopfs.