This version of the game definitely has potential, and I love a lot of the new art/scenes. However, for the time being, I would sincerely suggest anyone interested in this game seek out the HTML version under the same name still on Newgrounds. It's a significantly more complete version of this game, despite it being shelved a couple years ago.
(WHOLE BUNCH OF COMPARISONS/CRITIQUE BELOW)
When it comes to content, the Ren'py version is a combination of new writing, old writing from the HTML version, and updated writing from the HTML version to make it better fit the new engine. A lot of this new/updated writing is really enjoyable, and the new backgrounds/art are great! However, the HTML version has far more scenes, NPCs, and art. Playing the HTML version feels like a much more complete experience at the moment, but I'm hoping that as the Ren'py game updates it'll get more fleshed out.
Regarding story: as it is now, the new Ren'py game is significantly more linear, which makes sense given the focus on making the story easier to access. Unfortunately, this has some pretty bad side effects, such as limiting where you're allowed to go and what you can do by story progression. While some elements of that existed in the HTML version, it's still a much more open world to explore. Additionally, while the HTML version's story was harder to follow, it still felt far easier to progress than it does in the Ren'py version. At the moment, the Ren'py version's story progression is based almost entirely on trial and error, and it's sometimes hard to tell if/when you're actually using your time wisely. Gathering clues for the two password puzzles are prime examples of this; it's hard to tell if you have all the clues for the password unless you already know the password in advance. This... kind of defeats the purpose of the puzzle. The HTML version's story is a little harder to follow, but in my opinion, is much easier to actually progress through.
Another story-based thing in the Ren'py version of the game are the fights, of which I've seen a couple comments expressing some disappointment over. In the Ren'py version, fights are currently scripted wins/losses until their chapter is over, upon which they just... stop existing. In the HTML version, though, there were FAR more fights, they were actually repeatable at any point, and had a ton of outcomes based on various methods of winning/losing, unlocked fetishes, etc.. Plus, fights gave you money/items, which is always nice!
Additionally, the game mechanics in the HTML version are way more fleshed out than the Ren'py one, with a bunch of different transformation systems (various species, body part sizes, masculinity/femininity, muscle, etc.) that you could interact with to customize your character. At the moment, the Ren'py version has a scripted transformation that makes you into a mouse, and that's it, I think. There were also far more fetishes, additional fighting types, and optional content/paths to unlock that don't seem to exist in the current Ren'py game.
Lastly, the phone system in the Ren'py version is currently incredibly cumbersome to deal with. For those who don't know, you unlock the phone system after completing chapter 2, and it replaces all of the text prompts you usually use with a phone interface. Instead of clicking the "Talk to NPC" or "Go to location" text prompts on the screen, you click the "app" related to what you want, then click on the text prompt from there. From what I've read, it's planned to eventually make NPC encounters easier to find, so that you don't have to do a bunch of random encounters to find them. This is a great idea! However, at the moment, it just makes going places and interacting with NPCs much harder. Instead of just clicking the prompt to go to a place and being done, it now takes several clicks in different locations to accomplish the same task. Leaving the house, for instance, requires you to click off the NPC app, onto the location app, then click the text prompt, all with little animations. Additionally, the phone system currently removes all random encounters. This means that you can no longer farm items, see random events, or (most pressingly, in my opinion) quickly pass the time. Which ends up making it MUCH harder to get to the right time of day to talk to NPCs, and... kind of undermines the point of having the phone. Why have a system designed for easier NPC encounters make it harder to meet them at the right time? Needless to say, the phone system does not exist in the HTML version. In the HTML version, quite a few NPC encounters are frustrating to access due to being random events, but the majority of important NPC encounters aren't random at all-- you just go to the area at the right of time of day, and a prompt shows up.
I really, truly think the Ren'py version has a lot of potential, and I know making this into a good RPG game in the engine can be done. However, at the moment, I cannot recommend this version of the game over the HTML one.