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This is something I'm genuinely curious about. Do these ultra-wide monitors have the option to let you show a normal 16:9 resolution but have it just center it and then crop out the sides? I'm working on a 2d game right now (I know this isn't technically 2d but it plays as one) and I can tell you that the thought of having to accommodate these types of resolutions is kind of disheartening. 

As far as I am aware, yes. If the content aspect ratio is 16:9 it is displayed in the center of the screen with black bars to the left and right. So nothing to worry about unless your game selects the native screen resolution by default.