Forgot to mention item hightlighting. It looks nice (helps you tell if you're ready for interaction with the item when you aim at it) but I'm not sure about the overall increased brightness of items that can be picked up while they are just lying around in the map.
I guess I'd rather prefer to have a special hotkey that would somehow highlight them when it is pressed (switch) or while it is held down. Either with a yellow outline, as in the original game, or by increasing their brightness, like it currently is, or, maybe, with green overlay (like now when they are aimed at and active for interaction). Probaly brightness or outline would be better, since green overlay copies enemy VATS highlighting, and for those who would prefer to have this as a switch and would run around with this option turned on all the time having all items that can be picked up glowing green all the time would be weird (especially if, let's say, a bunch of bottles on a shelf in a bar would be actual items that can be stolen) but also highlighting items in green oerlay would look more "natural" and true to the lore / ingame world, as if it's actually your PipBoy somehow assists you in detecting them (much like the VATS system). Not sure how it should work lore-wise, though, since characters in Fallout don't have any retinal augmentations or special glasses or devices like monocles, connected to their PipBoy and placed over their eye (except for that device on the T-51Bb Power Armor helmet), but I still think that would look more authentic than just increased brightness or outilnes. And increased brightnes or outline could be still used for when teh item is actually targeted and ready for interaction with it (personally I specifically like when active items like switches or pickups are indicated with... not sure how to say that in english properly... well, angle brackets in the corners, like in Deus Ex 1, for example)
This came to my mind after I saw that enemies are surrounded with just a red square, some sides of which vanished depending on the angle at which the camera was facing them, on low-quality settings, like on that screenshot with a gecko stiuck inside the building with no doors.
At times it wasn't a full square but rather L, Г, П or U-shaped lines (in fact, it was pretty hard to capture a screenshot where it was a full square, because even teh slightest movement of the camera made one or two of the sides disappear).