This is a fun little game, I had trouble finding the theme at first but then I eventually locked myself out of an important part to resupply the towers! So I would say that there's definitely side effects to the tower placement more than usual in other tower defense games. It's not just about the strategic location but also the running distance to resupply and of course leaving a path open.
I had to turn off the music because it became repetitive quickly but I really enjoyed what you have made otherwise, good job!