I just played it!, very solid concept for a game, nowadays vampire survivors-like and roguelikes are very popular, if you want to build a full game in the future i really suggest to keep pushing on those genres.
Also, you always should use assets with a similar resolution, all the pixels in the game have to be the same size. For instance: Maybe if you scale a 16x16 sprite to fit the same size of a 32x32, it would look as each pixel in the 16x16 are twice as bigger than the 32x32 sprite, and this can make your game loose artistic consistency, but that's just a small tip from a artist xD
I'm very glad you liked my asset!