Um, I think I got a room where Spiders crawled over me, then I made a roll where my character blinked and all the spiders are gone. No consequences. If I remember correctly.
Edit: Lol, literally just launched the game again and the first room I walk into is the conservatory where bugs crawl on me. I shake them off and lose 1 sanity. Why do you ask about the bugs?
Edit2: or are you asking bugs in code? If so, the only thing I run into is an unknown error, where I try to walk into an unknown space when all the tiles are used up.
Edit3: Actual, I do remember a weird bug with Omens in the late game. Sometimes, an Omen will activate, blocking my ability to leave, but when the Omen finishes, the way to leave is still blocked. But I find that if I mess around with my items and omens in my inventory, activating various items, eventualy the way unblocks. I don't quite know what is up with that.