Cute little game!
Wow, the art in this game is spectacular. I like how all of the assets work very well together to make a unified theme. Although, I do wish it had a bit more "life" to it via some small animations (I was thinking a low framerate style could fit it nicely) but I know that adding that within a 48 hour time period is difficult.
Having a tutorial that is a wall of text before the game can make it hard to get started and understand how the game works, just having some text that guides the player on what to do for a first few levels can go a long way into actually getting them to understand how the game works.
It is also hard to get through a level when you need to plan out and predict everything you need to do beforehand, especially when there are a lot of changing steps involved. I found myself wanting some form of notepad to write down what I needed to do in order, so I could continue thinking ahead of what I needed without forgetting what I had done. Having some way to reset the level, or maybe even an undo would help a lot with letting players realize their mistakes and go back without having to fail the level outright.
The runes and potion "texture" were a cool way of introducing more levels to the potion making. I think there is room for many other additions too, like maybe the temperature of the pot or what is used to mix it? You could also maybe expand the game to have multiple pots that are being cooked at once and need to be mixed together?
Ideally, you could maybe reach a point to which players know what ingredients do what, and then they could work without nearly as much as the instruction list showing them every possible combination. Having ingredients be a bit more obvious as to what they'll do will help, within the first level a blue bottle makes the potion yellow, which can be confusing.
Overall, nice concept with a great visual style!
I really hope to see an explosion animation in the future :)