This is a rogue-lite amongst rogue-lites.
I say this because, while it keeps to the standards of the genre, it adds so much to the gameplay that it practically stands on its own.
Graphically, the pixelated style holds up. Nothing groundbreaking, but it holds its own. The sound effects were on par, although I really wish we could get some background music soon. The controls take a bit to get used to, otherwise it plays beautifully. The gameplay, however, is where Streets of Rogue takes off. With so much customization and potential builds/play styles, it does have the feel of bigger-name games.
I can't think of very many cons off the top of my head, which is strikingly odd when playing alpha builds.
Overall, this is a damn fine start to what could be a sleep hit next year. Good luck on development!