Well thought out; every time I thought "well there's only so much you can do with this" there's a new mechanic thrown in.
Conveyors were a little buggy but otherwise it works well.
If I had to level criticism, the "only once" here can be a bit of a two-edged sword: no allowance for care or planning so some levels with the red clouds (swarms?) can be a little too trial and error.
But, you went full with the theme, and honestly this works well for the most part~
A top down perspective might have been kinder, but it's not really an issue with the grid alignment