Hi, thank you so much for your kind words about my game! I didn't create the game with one MC and one player in mind, but I think you could give it a go. It would be a somewhat different story (of being a lonely witch, without the support of a coven) but it could be an interesting story to explore. I'd suggest increasing the number of starting plants for one player, to balance out lack of support that usually comes from other characters.
If you try it, let me know how it goes!