Wish I were that lucky, cause I got the same clue for today (499, 233) and likewise for when I retried with (499, 200). Edit: I think I've been getting unlucky with your strat (I don't want to seem like I'm doubting your strategy, but genuinely (512, 243) would've given 3s for yesterday and today)
Today, I went (499, 246, 407). With 499, I had (499-x)'s largest prime divisor is 23, so I subtracted 11 * 23 = 253 to get 246, which is divisible by 2 and 3. Since I it returned the largest prime divisor is 23 clue again, I thought it was most likely to be 5 * 23 or 7 * 23 away. Otherwise, I'd get the "x and 246's largest divisor was 2" type clue. I was lucky enough to chose the latter.
However, yes, this is something that requires experimenting over time. You're correct that (512, 243) narrows today's down to a single solution, which makes it at least 0.5 guesses better than (499, 246) for today's number.
Except by accident, I have *not* played with having second guesses that aren't possible solutions. There may be certain clues where that's the optimal solution, but instinctively that feels wrong. However, that may also depend on what one's goal is...to minimize the average number of guesses or to minimize the number of losses. Those could yield slightly different strategies.
That does affect how I play Wordle, Dordle, and Quordle. Because I play against others, I used strategies that are optimized to beat my two friends at the slight increased risk of losing the game. Most notably, I stopped using ADIEU as a starter, because that made getting it in two extremely difficult and three less frequent than four.
For Dordle and Quordle, I do sometimes use words that aren't possible solutions to more efficiently eliminate letters. For example, I'd guess if the game returns -OUND, I might guess BUMPH to test four candidates for the first letter...even though that's British slang and would never be the solution. So, I'm open to something like your 243/729 second guess being best. I just feel it isn't for the reasons described elsewhere in the thread.
I will continue playing it both ways to compare.