I ran into a bug where I may have been clicking to fast but the cowgirl ran into me and everything on the map just froze, unable to interact. When I returned to the menu and continue back to the game it still doesn't do anything. The buttons on the top all work.
So I suggest adding an "Abandon Run" button in the menu, that way everything in the previous run may get wiped off and we can start over.
Other than that I also suggest letting the player inspect the items we can pick up or letting us drop items, since not all monsters are able to be given items.