I had a friend with windows 10 mess with it. And this was the solution we found.
If you run as administrator you should get a different pop up saying that "Windows prevented an unrecognized app from starting"
There should be a "More info" button you can press on that same window that will give you the option to open the game anyways. Do that and it should run properly, but if it doesn't let me know and I can try looking into it further.
Strangely enough that's what happened when I first tried opening it, but after I clicked the option to run it anyway that's when it started saying "this app can't run on your PC" And running it on administrator is just saying the exact same thing too.
Tried troubleshooting it as well which was no use, even tried deleting it and trying again but it just said the same thing again.
Yeah that's real strange. Unfortunately I can't say I've seen that issue on the computers I was able to test on so I'm really not sure how to resolve it. The only thing I can really suggest for now is to delete it and wait for the November 28th update, and see if that version gives you the same issues or not. I'll see if I can find an alternate way to package the game for the update as well, that might be more user friendly. Sorry I couldn't be more help!