Without an error message (when opened as a stand-alone program there will be 2 windows, the game and a command prompt which will report problems), or something more specific it's difficult to tell the cause. If you are using any mods, it would help to know which ones.
There is only one known fatal error for 0.5.25 at the moment(https://itch.io/t/542925/bug). That bug should mostly effect progresses started before this version. The discord is a good place to get quick feedback and an easy way to upload a save file for proper examination.