i really don't have enough informations, i started learning about 2d optimization and graphics thing. hope i'll do better in the future :)
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Here's a few tips since you're using Unity.
1) Use Linear color space and not Gamma.
Edit > Project Settings > Player > set "Color Space" to "Linear" (it's Gamma by default)
https://docs.unity3d.com/Manual/LinearRendering-LinearOrGammaWorkflow.html
2) Use deferred rendering when possible for scene cameras.
Select the Camera > Rendering Path > Deferred
https://docs.unity3d.com/Manual/RenderTech-DeferredShading.html
3) Checkout occlusion culling if you don't know what it is
https://docs.unity3d.com/Manual/OcclusionCulling.html
4) Batch draw calls
https://docs.unity3d.com/Manual/DrawCallBatching.html
5) General optimisation tips for graphics
https://docs.unity3d.com/Manual/OptimizingGraphicsPerformance.html