More items and more strategies is a good thing??? It would get super boring if you had to do the same strategy every time. It's great that the devs have been constantly updating the game by adding and balancing items. (and more skins! :) )
The more recent addition of the item list definitely makes the "too many items to keep track of" issue manageable. It's great to have a game that has a "wiki" built in.
They seem pretty passionate about this game and it has been great to see it grow since I first played it on release. :)
That being said; there will probably be a point where there are too many items in the pool, so it would be hard to go a certain strategy because you may never see the items you need. Maybe at that point they can implement some sort of "remove item from pool" function or maybe "decks/subclasses" where you can choose what items show up for you. I know they already have certain items per class, but there may need to be something to help lessen the item pool further if more items are added.