Disagree with Mado on the writing style, think it's neat, do agree with him that slow down makes for a more boring experience.
Map generation does not seem to work flawlessly, produced some initial runs where you could not progress at all.
Give her a health bar and have the gameover be some sort of lewd stuff, heading further into the Binding of Isaac route is probably an endless flow of patreon money. Item combinations, items working in different ways depending on what bondage is applied to you, and projectiles right from the start that change based on item pickups.
But the slowdown has to go, it makes it tedious to explore and see all the funny and clever details you are known for, such as stepping on a mine and being blasted into another map.