Depending on your Mac version, it might unfortunately just not be supported anymore:
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Note that Apple removed support for RPG Maker MV (which Lust Doll+ runs on) with macOS Big Sur 11.0 and later. If you are using version 11+, you might need to play on browser, or use another device.
Source: https://forums.rpgmakerweb.com/index.php?threads/regarding-future-rpg-maker-mv-m...