In terms of colour blindness, we've tried to 'double encode' information as much as possible throughout the game. We do use colour to distinguish information (for example, Forest encounters have a green background and Loch encounters have blue, etc). However, all information is paired with unique illustrations and icons that would work in B&W. As the designer, I've not looked into the contrast ratings or colour blindness variations, so your mileage may vary. I've just updated the itch page with a digital preview of the book, so have a flick through!
In terms of printer friendly, the full book is 220 pages long, so at home printing will be expensive no matter what you do. We do have physical copies for sale in the US and UK, so you may want to check print quotes versus buying the book anyway. Wherever you buy the book, it should also come with all the digital files too. The PDF is loaded with plenty of bookmarks, so it's very functional for digital viewing.
In terms of remediation, the game's PDF is untagged and there's no alt text or plain text companions, but it's something we'd like to look into, maybe for a big anniversary Kickstarter reprint.