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The game plays great through Wine. I did it using Lutris.

The "Grow on defeat" perk doesn't function. 

One needs to load a new area or save (maybe, I haven't tried) in order for new bindable skills to show up in your toolbar after they are unlocked in the skill tree.

I haven't found a way to unbind a skill, in which case I feel there should be a method of doing so. 

The skill "Give Up" keeps appearing in my toolbar every time I load a new level.

The Giant Rat outside the sewers in the town doesn't actually grow larger despite doing the animations. It would be pretty cool if it actually DID grow.