If in full screen and monitor goes to sleep, upon awakening monitor game is no longer in full screen and cannot move mouse any further than the top left quadrant of the game screen before mouse leaves application. Moving the mouse around the application and attempting to continue movement only resets position of mouse in accordance with where you rejoin the application and still will not allow me to move past top left quadrant.
Post: If you find yourself in this position, hold the right mouse button down and it will allow you to drag further inside the application to fix your settings.